Prophylactic treatment of migraine with gamma-linolenic and alpha-linolenic acids.
نویسندگان
چکیده
Polyunsaturated fatty acids (PUFA) were administered to 168 patients over a period of 6 months in an open-label uncontrolled study. In 129 patients available for study, 86% experienced reduction in severity, frequency and duration of migraine attacks, 22% became free of migraine and more than 90% had reduced nausea and vomiting. Self-medication changed to simple analgesics in the majority except in 14% of patients without improvement.
منابع مشابه
Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial.
OBJECTIVE To explore the separate and combined effects of simvastatin and a low-saturated diet rich in alpha-linolenic acid on serum fatty acids. METHODS AND RESULTS 120 hypercholesterolemic men were randomly allocated to a habitual diet or dietary treatment group and to receive, in random order, simvastatin 20 mg/d or placebo, each for 12 weeks, in a double-blind manner. Dietary treatment de...
متن کاملGamma linolenic acid (GLA)
85. Arnold, L. E., Kleykamp, D., Votolato, N. A., Taylor, W. A., Kontras, S. B., and Tobin, K. Gamma-linolenic acid for attention-deficit hyperactivity disorder: placebo-controlled comparison to D-amphetamine. Biol.Psychiatry 1-151989;25(2):222-228. View urgess, J. R. other disruptive behaviors. Lipids 2003;38(10):100786. Stevens, L., Zhang, W., Peck, L., Kuczek, T., Grevstad, N., Mahon, A., Ze...
متن کاملEvening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids.
The serum concentration of lipids and composition of fatty acids after overnight fasting were studied in 18 patients with rheumatoid arthritis treated for 12 weeks with either 20 ml of evening primrose oil containing 9% of gamma-linolenic acid or olive oil. The serum concentrations of oleic acid, eicosapentaenoic acid, and apolipoprotein B decreased and those of linoleic acid, gamma-linolenic a...
متن کاملDifferential oxidation of saturated and unsaturated fatty acids in vivo in the rat.
The oxidation rates of lauric, myristic, palmitic, stearic, oleic, alpha-linolenic, linoleic, kappa-linolenic, dihomo-gamma-linolenic and arachidonic acids were studied by use of a radioisotope tracer technique in weanling rats at rest in a metabolism chamber over 24 h. Of the saturated fatty acids, lauric acid (12:0) was the most efficient energy substrate: the longer the chain length of the s...
متن کاملInhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids.
Human or rat microsomal 5 alpha-reductase activity, as measured by enzymic conversion of testosterone into 5 alpha-dihydrotestosterone or by binding of a competitive inhibitor, [3H]17 beta-NN-diethulcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one ([3H]4-MA) to the reductase, is inhibited by low concentrations (less than 10 microM) of certain polyunsaturated fatty acids. The relative inhibitory...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cephalalgia : an international journal of headache
دوره 17 2 شماره
صفحات -
تاریخ انتشار 1997